Intracellular APEX2 mostly generates GS (Extended Data Fig
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this is a standard precaution unrelated to the tirzepatide itself but tied to your nutritional status during weight loss
DeBose-Boyd, R
References Semaglutide for managing overweight and obesity (TA875) , National Institute for Health and Care Excellence, 2023 [Accessed 22 April 2026] Semaglutide for reducing the risk of major adverse cardiovascular events in people with cardiovascular disease and overweight or obesity (GID-TA11544) , National Institute for Health and Care Excellence, 2026 [Accessed 22 April 2026] Semaglutide and cardiovascular outcomes in obesity without diabetes (SELECT) , New England Journal of Medicine, 2023 [Accessed 22 April 2026] Oral semaglutide 25 mg in adults with overweight or obesity (OASIS 4) , New England Journal of Medicine, 2025 [Accessed 22 April 2026] Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension , Diabetes, Obesity and Metabolism, 2022 [Accessed 22 April 2026] NHS prescription charges , NHS, 2023 [Accessed 22 April 2026] Semaglutide for reducing the risk of major adverse cardiovascular events in people with cardiovascular disease and overweight or obesity (TA1152) , National Institute for Health and Care Excellence, May 2026 [Accessed 16 June 2026] First GLP-1 tablet for weight loss approved in the UK , Medicines and Healthcare products Regulatory Agency, 2026 [Accessed 16 June 2026]
Both can be highly effective
